Background:
@EN Early reperfusion after acute myocardial infarction is known to be effective in salvaging myocardium and hence improving early and late mortality and morbidity. The late reperfusion by percutaneous transluminal coronary angioplasty(PTCA) is
also
reported to be helpful in improving mortality and morbidity also, however the exact mechanism is not known when the salvage of myocardium is not expected.
@ES Methods:
@EN In this study, 24 acute myocardial infarction patients who had not been undergone reperfusion therapy within 6 hours or those who had been failed to be recanalized were subjected to study. The patients were divided into two groups, group I.
those
who had little ischemic myocardium around the infarct(11 patients, all male. 59.1±9.8years) and group II, those who had considerable ischemica area around the infarct zone(13 patients. M:F=3.3:1, 60.9±9.7 years) revealed by myocardial perfusion
scanning with 201TI or 99mTc-MIBI. The area of ischemia and infarction, defect volume ration and left ventricular dimensions and global functions were measured before and after PTCA. The mortality and morbidity were also observed.
@ES Results:
@EN In group I the associated risk factors were hypertension in 5, hypercholesterolemia. 2 and smoking 5 patients and in group II hypertension in 5, hypercholesterolemia, 4, smoking, 7 and diabetes mellitus, 2 patients.
The PTCA was peformed 10.2±4.9days in group I and 10.5±6.6days in group II after the admission. The infarct related arteries were left anterior descending artery in 12, left circumflex artery in 2 and right coronary artery in 10.
Echocardiographic variables, i.e. left ventricular end-diastolic volume, left ventricular end-systolic volume, ejection fraction of the left ventricle and the E to A ratio of mitral flow measured by doppler echocardiography were compared before
and
after PTCA in each group. The variables were not different between two groups and were not changed after PTCA.
Myocardial perfusion scanning revealed significantly decreased defect area(p<0.05), infarct area(p<0.005) and defect volume ratio(p<0.05) after PTCA in group II. In group I. 6 patients out of 11 showed improved infarct area and defect volume
ratio,
but
the mean of the group was not different before and after PTCA. There was neither mortality nor nonfatal infarction during follow up period of 15.9±3.8months in group I and 13.8±3.8months in group II.
@ES Conclusion:
@EN Above results suggested that the delayed PTCA was efficacious in reducing perfusion defect area, infarct area and defect volume ratio in group II and in some patients of group I also and that the delayed PTCA might be effective in preventing
further
dilation of the left ventricle and further deterioration of the ventricular functions in either group of the patients.
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